Effects of Aqueous Extract of Cumin Seed (Cuminum cyminum) on the Structure and Function of Albino Rat Kidneys Treated with Dibutyl Phthalate

This study was aimed to investigate the effects of Cuminum cyminum seed aqueous extract on function and histological structure rat kidney treated with dibutyl phthalate (DBP). Eighteen albino rats weighing 190-240g aged 10-12 weeks were used for this which went 28 days. The divided into three groups (each six animals): 1st group: control given food tap water, 2nd group DBP (420mg/Kg. B.W.) water diet, 3rd fed cumin plant orally at a daily dose (200 mg/kg (420mg/kg. drinking diet daily. Kidney liver parameters measured examined. Results showed that significantly increased creatinine, urea as well AST ALT, while decreased ALP level, destruction, hemorrhage inflammation in kidney. Cumin ALT level but elevated concluded may cause oxidative stress Despite hepatoprotective role cumin, it interacts DPB increases bleeding